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Major Employers
| Employer | Number of Employees |
|---|---|
| Southern Illinois University | 5,779 |
| Memorial Hospital of Carbondale | 1,274 |
| SIH System Offices | 627 |
| SIH Medical Group | 511 |
| Carbondale School Employees (K-12) | 403 |
| Neuro Restorative | 400 |
| Walmart Supercenter | 324 |
| Illinois Department of Transportation | 291 |
| City of Carbondale | 261 |
| Com-Pac, Inc. | 240 |
| Lowe's | 176 |
| Brehm Preparatory School | 167 |
| University Mall (Corporate & Tenants) | 160 |
| Kroger | 160 |
| Center for Medical Arts | 124 |
| Schnucks | 108 |
| E.T. Simonds | 100 |
| U.S. Postal Service | 62 |
| Southern Illinoisan | 51 |
| Centerstone |